GLP-1 medications work. Semaglutide produced an average 14.9% body weight reduction in the STEP 1 trial. Tirzepatide hit 22.5% at its highest dose in SURMOUNT-1. Telehealth has made both accessible without a clinic visit: you can get a prescription, have medication shipped to your door, and never see a doctor in person.
The problem is figuring out which of the dozen-plus platforms is worth trusting. Pricing is murky by design on some of them. "Physician oversight" can mean very different things. And after the FDA issued warning letters to more than 55 companies for misleading marketing in 2025, a cleaner line has formed between the platforms operating legitimately and those that aren't. This guide covers four we've reviewed.
Pricing was verified in May 2026 and changes often. Check each clinic's site before signing up.
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Our picks at a glance
What GLP-1 weight loss medication actually is
Your gut releases GLP-1 (glucagon-like peptide-1) after you eat. It slows digestion and signals your brain that you're full. GLP-1 receptor agonists like semaglutide and tirzepatide replicate that signal pharmacologically. The result is substantially reduced appetite and, when doses are right, meaningful weight loss. The medication isn't doing the eating for you; it's removing the physiological pressure to overeat.
Semaglutide is the molecule in Ozempic (approved for Type 2 diabetes) and Wegovy (approved for weight management). Tirzepatide targets both GLP-1 and GIP receptors, which seems to be why it outperforms semaglutide in trials. Both come in compounded versions that cost a fraction of the branded price. Wegovy runs over $1,000/month without insurance; the same active ingredient from a telehealth clinic typically runs $130 to $250.
Compounded versions use the same active ingredient but are made by 503A or 503B FDA-registered compounding pharmacies rather than pharmaceutical manufacturers. This distinction matters for two reasons: quality controls differ, and the regulatory rules around compounded GLP-1s have shifted. The FDA declared the semaglutide shortage resolved in February 2025, meaning compounding pharmacies that were relying on the shortage exception had to stop by spring 2025. Clinics operating legitimately have adjusted. If a clinic won't tell you which pharmacy makes their medication, that tells you something.
What to look for in an online GLP-1 clinic
Some of this is obvious in retrospect but easy to skip when you're just trying to get started.
Real physician review. Every intake questionnaire eventually reaches someone. The question is whether that someone is a licensed physician actually reviewing your health history and medications, or a system optimized to approve anyone with a qualifying BMI. If a clinic won't say clearly, assume it's the latter.
Named compounding pharmacy. 503A pharmacies compound for individual patients under state oversight. 503B outsourcing facilities face FDA inspections and pharmaceutical-grade manufacturing standards. Both are legitimate. A clinic that can't or won't name their pharmacy is a problem.
All-in pricing. Some platforms bundle everything: consultation, medication, supplies, shipping, follow-up. Others charge separately for each piece. The headline price is meaningless if you can't determine your real monthly cost.
Medical access after day one. Titrating your dose takes months. Side effects are worst in the first six weeks. You need a provider you can actually reach once the medication arrives, not a customer service inbox with a 72-hour response time.
State availability. Most major platforms cover 45 or more states, but individual medications sometimes have state-level restrictions even on nationally available platforms. Takes a minute to check; saves 20 minutes on an intake form you'll have to abandon.
The clinics
All four below require physician review, use licensed compounding pharmacies, and operate in most US states. Here's how they differ, and what to know before signing up.
TrimRx
- Starting price
- From $179/mo
- Medications
- Semaglutide, Tirzepatide
- Consult type
- Async + support
- Best for
- Support & infrastructure
- Trustpilot
- 3.3★ (727 reviews)
- State coverage
- Most states
Oak Loves You
- Starting price
- From $130/mo
- Medications
- Semaglutide, Tirzepatide
- Consult type
- Async
- Best for
- Budget-conscious
- Trustpilot
- 4.6★ (46 reviews)
- State coverage
- Most states
Eden Health
- Starting price
- From $149/mo
- Medications
- Semaglutide, Tirzepatide
- Consult type
- Async
- Best for
- Long-term programs
- State coverage
- Most states
PeterMD
- Starting price
- From $165/mo
- Medications
- Sema + BPC-157, Sermorelin, more
- Consult type
- Async (labs req.)
- Best for
- GLP-1 + peptide breadth
- State coverage
- Most (AL/ID restrictions)
| TrimRx | Oak Loves You | Eden Health | PeterMD | |
|---|---|---|---|---|
| Rating | ||||
| Starting price | From $179/mo | From $130/mo | From $149/mo | From $165/mo |
| Medications | Semaglutide, Tirzepatide | Semaglutide, Tirzepatide | Semaglutide, Tirzepatide | Sema + BPC-157, Sermorelin, more |
| Consult type | Async + support | Async | Async | Async (labs req.) |
| Best for | Support & infrastructure | Budget-conscious | Long-term programs | GLP-1 + peptide breadth |
| Trustpilot | 3.3★ (727 reviews) | 4.6★ (46 reviews) | N/A | N/A |
| State coverage | Most states | Most states | Most states | Most (AL/ID restrictions) |
TrimRx
TrimRx is one of the more established dedicated GLP-1 telehealth platforms: BBB-accredited, LegitScript-certified, and pricing that bundles everything into a single monthly number. That last part matters more than it sounds. When consultations, supplies, shipping, and 24/7 support are all included, you can actually compare their price against competitors instead of doing mental math to figure out the real total.
What they offer: Compounded semaglutide and tirzepatide, plus brand-name options (Ozempic, Wegovy, Mounjaro, Zepbound) for patients who prefer them or have insurance coverage.
Who it's best for: Someone who wants a dedicated GLP-1 specialist and doesn't want to chase down support when they need a dose adjustment. The unlimited provider check-ins are the real differentiator; most patients need at least a few over the course of treatment.
Pricing: Semaglutide $179 to $199/month. Tirzepatide $259 to $349/month. Pricing is publicly listed on their site.
The intake process: Online health assessment, physician review, medication ships with injection supplies included if approved.
Pros
- All-inclusive pricing: consultations, medication, supplies, and shipping bundled
- Unlimited provider check-ins with 24/7 support access
- LegitScript-certified and BBB-accredited
- Both compounded and brand-name options available (Ozempic, Wegovy, Mounjaro, Zepbound)
- Oral GLP-1 option available for patients who prefer not to inject
- Injection kit and supplies included — nothing to source separately
Good to know
- Semaglutide starts higher than Oak's entry price; the all-in bundling is what you're paying for
Oak Loves You
Oak launched in late 2023 with a simple pitch: the lowest published price in the market, no membership fee, no subscription. Semaglutide from $130/month and tirzepatide from $199/month are hard to argue with if cost is the primary factor. Free shipping. Free health coaching. Month-to-month with no lock-in.
What they offer: Compounded semaglutide and tirzepatide from licensed US compounding pharmacies. Mobile app for progress tracking and medication reminders.
Who it's best for: Someone who's already done their research, is comfortable with an async-only model, and just wants the medication at a reasonable price without friction. Less ideal if you need a lot of hand-holding or want an established track record behind your provider.
Pricing: Semaglutide from $130/month. Tirzepatide from $199/month. No membership fee. Free shipping. Price matching available.
The intake process: Online questionnaire reviewed by a board-certified physician licensed in your state. Typically fast turnaround.
A note on track record: Oak claims 10,000+ patients and holds a 4.6-star Trustpilot rating (based on 46 reviews). That's not a meaningful sample yet. The platform operates legitimately, but it hasn't been around long enough to know how it handles problems at scale. If you're the kind of person who wants years of reviews before committing, this isn't that.
Pros
- Lowest semaglutide price in this comparison at $130/mo
- No membership fee and no subscription required
- Free shipping and free health coaching included
- Month-to-month flexibility: pay and reassess
- One price covers all dose levels — no price creep as you titrate up
- Same-day intake review in most cases
Good to know
- Launched in 2023, so the review base is still growing
- Trustpilot score of 4.6 is promising but reflects fewer than 50 reviews at this point
Eden Health
Eden has been operating since 2004, though their GLP-1 program is a more recent addition. What sets them apart structurally is flat-fee pricing: your monthly cost doesn't increase as your dose goes up. On most other platforms it does, which means patients who need to titrate to a full therapeutic dose end up paying meaningfully more than the advertised price. Eden removes that uncertainty.
What they offer: Compounded semaglutide and tirzepatide. Brand-name options for qualifying patients. Eden currently offers a first-month discount through this link; check their site to confirm it's still active before signing up.
Who it's best for: Someone who wants a focused GLP-1 specialist with an established patient base and predictable pricing. Particularly good for people planning to stay on GLP-1 medication for a year or more, where the flat-fee structure meaningfully reduces total cost compared to platforms that charge more at higher doses.
Pricing: Semaglutide $149 first month, $249/month after. Tirzepatide $249 first month, $329/month after. Price stays flat as you titrate up. No membership fee, cancel anytime.
The intake process: Short health questionnaire reviewed by a licensed provider. In-app care team chat for ongoing access.
Pros
- Flat-fee pricing: monthly cost stays the same even as dose increases
- No membership fee, cancel anytime
- In-app chat with care team for ongoing support
- Established platform with significant patient base
- Meal plans, workout routines, and nutrition coaching included in-app
- Shot tracker to log injections and stay consistent on your titration schedule
Good to know
- Standard monthly rate ($249/mo) is higher than Oak's entry price
- Insurance not accepted; HSA/FSA cards may cover some costs
PeterMD
PeterMD started in TRT and has kept that formulary as they've expanded into GLP-1 medications. The result is the only clinic in this comparison where you can do semaglutide for weight loss and add BPC-157 for recovery, Sermorelin for growth hormone support, or CJC-1295/Ipamorelin without switching providers. If you're only interested in GLP-1 medication, that breadth is irrelevant. If you're thinking about peptide therapy for weight loss or recovery alongside GLP-1, it changes the calculus.
What they offer: Compounded semaglutide and tirzepatide for weight loss, plus a full peptide formulary: BPC-157, Sermorelin, CJC-1295/Ipamorelin, and TRT. No other clinic in this comparison comes close on selection.
Who it's best for: Someone who wants GLP-1 as the main event and wants the option to add peptides later without switching platforms. Also a good fit for anyone who finds it reassuring that their protocol is built around actual bloodwork rather than a questionnaire.
Pricing: Semaglutide from approximately $165/month. Tirzepatide pricing requires direct contact with PeterMD. Accepts HSA and FSA cards; eligibility typically requires a documented obesity or qualifying comorbidity diagnosis.
The intake process: Lab testing through Quest Diagnostics is required, or recent existing results work. Labs take 5 to 7 business days, then asynchronous provider review and personalized treatment plan.
State availability: Semaglutide not available in Alabama or Idaho through PeterMD. Tirzepatide has broader state restrictions, so confirm availability before starting the intake process.
Pros
- Only clinic here that also prescribes BPC-157, Sermorelin, and CJC-1295/Ipamorelin
- Accepts HSA and FSA cards
- Lower semaglutide starting price than TrimRx or Eden
- Lab-based intake means your protocol is grounded in actual bloodwork
- TRT program available on the same platform if hormonal optimization is part of your plan
- Recent existing labs accepted — no need to repeat bloodwork you already have
Good to know
- Lab work through Quest adds about a week to your start time, but your protocol will be grounded in real bloodwork
- Check state availability before starting intake: semaglutide not available in AL or ID
- Tirzepatide pricing requires a direct quote from PeterMD
How to choose based on your situation
Here's what actually matters, depending on where you're starting from.
The cheapest option is Oak, and it's not close. $130/month with no membership fee or subscription is a stronger deal than anything else in this guide. The only real trade-off is that Oak is newer. If a few years of reviews makes you more comfortable than one, TrimRx or Eden give you that. But on price, Oak wins.
TrimRx makes the most sense if you want infrastructure. Unlimited provider check-ins, 24/7 access, all-in pricing. It's set up for someone who will actually use the support. The billing complaints on Trustpilot are worth knowing about, but the underlying product is solid for patients who engage with it.
PeterMD is the only option if peptides are part of your plan. If semaglutide now and potentially BPC-157 or a growth hormone secretagogue later is the scenario you're planning for, you can't get there with the other three clinics. The lab requirement adds a week to the start. Some people see that as friction; others see it as the whole point. You can read more about the full range of peptides for weight loss in our dedicated breakdown.
Eden is worth it for longer-term patients. The flat-fee structure saves real money over twelve months if you're titrating up to a therapeutic dose. If you're thinking about six months or less, the savings are smaller and Oak's price advantage likely outweighs it.
For a broader comparison that includes non-GLP-1 peptide options and more platforms, our peptide clinic guide covers more ground. If you're still evaluating whether GLP-1 therapy is appropriate for your situation at all, our safety overview covers what the evidence actually shows.
What to expect from GLP-1 treatment
Most people notice appetite reduction in the first two to four weeks. Visible weight loss (the kind that shows on a scale) typically starts between weeks four and twelve as doses increase. The STEP 1 trial tracked 1,961 participants for 68 weeks and showed an average 14.9% body weight reduction at the full 2.4mg semaglutide dose. For someone starting at 160 pounds, that's about 24 pounds.
Tirzepatide tends to outperform those numbers. SURMOUNT-1 found 16.0% weight loss at 5mg, 21.4% at 10mg, and 22.5% at 15mg over 72 weeks. These are clinical trial figures under controlled conditions. Individual results vary based on diet, starting weight, and dose tolerance.
Side effects are front-loaded. About 39% of users report nausea, per a Penn Medicine analysis of over 400,000 patient reports. It peaks in weeks two through six and improves for most people by week twelve. Fatigue, vomiting, and constipation follow in frequency. The practical advice that actually helps: small meals, eat slowly, stay hydrated, don't skip doses.
The harder thing to hear: weight usually comes back when you stop. A 2026 Lancet study found an average 9.9 kg regain in the first year after discontinuing semaglutide, with most patients near their starting weight by 18 months. GLP-1 medications work while you're taking them. What you do with that window (whether you use the reduced appetite to genuinely change your eating patterns or just eat less of the same things) matters for what happens after. Staying on a lower maintenance dose rather than stopping completely is an option many providers now recommend; worth discussing with yours before you start.
Frequently Asked Questions
Same active ingredient, different product. Ozempic is manufactured by Novo Nordisk under FDA oversight with full clinical trial data behind it. Compounded semaglutide is made by a licensed 503A or 503B pharmacy for individual patients, though it hasn't been through the FDA approval process itself. The FDA has also specifically warned compounders not to use semaglutide salts (acetate or sodium forms) in place of the approved base form, which is one reason pharmacy sourcing matters. The molecule is the same. The manufacturing controls are not.
Compounded semaglutide from the platforms in this guide runs $130/month (Oak Loves You) to $179 to $249/month (TrimRx, Eden). Compounded tirzepatide is $199 to $349/month depending on the platform. Brand-name Wegovy or Zepbound without insurance is over $1,000/month. Most of these clinics don't accept insurance for compounded GLP-1s, though some allow HSA/FSA for consultation costs. The number that matters is total monthly cost (shipping, supplies, and follow-ups included), not just the medication price alone.
Yes, always. Semaglutide is a prescription drug whether it's brand-name or compounded. Every clinic in this guide requires a licensed physician to review your case before anything ships. Any platform offering semaglutide without physician involvement is operating outside the law. That's not a gray area.
All four operate broadly, but specific medications have state-level restrictions. PeterMD can't prescribe semaglutide in Alabama or Idaho, and tirzepatide restrictions are wider there and in several other states. If your state might be affected, check with the clinic before filling out the intake form. The process screens for this, but it's faster to ask first.
Appetite comes back, and weight usually follows. The 2026 Lancet study found an average 9.9 kg regain in the first year after stopping, with most patients near their starting weight by 18 months. That's not a surprise: the medication works while you're taking it. What you do during treatment matters for what happens after. The patients who maintain more of the weight loss tend to be the ones who genuinely changed their eating patterns rather than just eating less of the same things. Staying on a lower maintenance dose rather than stopping completely is an option many providers now recommend; discuss it with yours before you start.